Early successful orchidopexy does not prevent from developing azoospermia

Early successful orchidopexy does not prevent from developing azoospermia.

INTRODUCTION The incidence of Ad spermatogonia (stem cells for fertility) was assessed in 20 cryptorchid patients, all of whom had a successful orchidopexy in childhood but developed azoospermia following puberty. MATERIALS AND METHODS From a cohort of 231 patients who had a semen analysis following successful orchidopexy 20 patients (9%) had azoospermia. The patients were classified into 2 g...

Does early orchidopexy improve fertility?

Cryptorchidism or undescended testis (UDT) is a common problem in the pediatric male population. While spontaneous testicular descent occurs in the majority of cases, orchidopexy is the definitive treatment in those with remaining cryptorchid testis. A long established sequela to cryptorchidism is reduced fertility in the adult male and recent guidelines have advocated for earlier orchidopexy a...

Cimetidine therapy does not prevent rebleeding from peptic ulceration.

One-hundred and five patients admitted to hospital with symptoms of acute upper gastrointestinal haemorrhage shown at endoscopy to be due to peptic ulceration were entered into a prospective double-blind controlled trial of cimetidine versus placebo therapy. The trial therapy was commenced within 12 hr of admission and continued for 7 days. Cimetidine therapy made no difference to the transfusi...

Ig Allotypic Inclusion Does Not Prevent B

Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term.

BACKGROUND/AIMS Transactivated hepatic stellate cells (HSCs) represent the key source of extra cellular matrix (ECM) in fibrotic liver. Imatinib, a potent inhibitor of the PDGF receptor tyrosine kinase, reduces HSC proliferation and fibrogenesis when treatment is initiated before fibrosis has developed. We tested the antifibrotic potential of imatinib in ongoing liver injury and in established ...